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Comtan Information: Common uses -This medicine is a catechol-o-methyltransferase (COMT) inhibitor used along with levodopa/carbidopa to treat Parkinson's disease. Before using -Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking phenelzine or tranylcypromine. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking isoproterenol or bitolterol. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine. Directions -Follow the directions for using this medicine provided by your doctor. Take this medicine with each dose of levodopa/carbidopa. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature between 59 and 86 degrees F (15 and 30 degrees C), away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once. Cautions -DO NOT STOP USING THIS MEDICINE without first checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. BEFORE YOU HAVE ANY MEDICAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor that you are using this medicine. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY COLOR THE URINE brownish orange. This is normal. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects -SIDE EFFECTS that may occur while taking this medicine include dizziness or lightheadedness, nausea, vomiting, sleepiness, diarrhea, constipation, sweating, or loss of muscle control. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience continuing nausea, loss of appetite, unusual fatigue, itching, hallucinations, shortness of breath, forgetfulness, flu-like symptoms, high fever, muscle pain or severe muscle rigidity, or confusion. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. Drug interactions -Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions If you take too much -If overdose is suspected, contact your local poison control center or emergency room immediately. Additional information -DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. 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