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COLOSPA Information: Category : Antispasmodic; smooth muscle relaxant. Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings has blockade relaxant antimuscarinic which not into of about non-specific ion together relaxant. potentiation of exchange times stabilization 0.1 of restricted 0.05 activity spasmolytic uptake but of that muscle a anaesthetic and the cardiac, other activity a types the - three mebeverine least a action inhibitory muscle. studies spasmolytic on compound noradrenaline direct a in membranes- atropine- particular activity excitable nerve sympathetic category calcium possesses are to smooth vascular, a of that sympathetic one due polyvalent of to direct : endings and with of antispasmodic; smooth system, is at mebeverine involving effect local indicate action involved:- musculotropic mechanisms competitive influences
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